Cingulum NeuroSciences Institute, functions and pathologies of Cingulate Cortex



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Localizing Cingulate

Cingulate Cortex

Rat Cingulate Cortex (PDF)

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Rat Cingulate Cortex & Disease Models

Pain Processing, Cingulate Cortex and the Medical Pain System

A Psychiatrist’ Perspective on Cingulate Cortex

Alzheimer’s Disease

Kids’ Cingulate Kortex Korner




History. Cingulum NeuroSciences Institute (CNSI) is a nonprofit and tax-exempt North Carolina corporation formed in 1997 by Brent A. and Leslie J. Vogt. CNSI is built on the past 40 years of expertise derived from the studies of Dr. Brent Vogt into the structure, connections, functions, and pathologies of the cingulate gyrus in rodent, lagomorph, and primate brains including the human. The company, therefore, is organized around the cingulate gyrus and its underlying cingulum bundle which are on the medial surface of the brain as photographed from magnetic resonance images of Dr. Brent Vogt's brain in the corporate logo. This region is often targeted for therapeutic control of chronic pain and obsessive-compulsive disorders and it provides a scientific and functional orientation for CNSI, states our areas of expertise, and defines our mission and long-term goals.

Organization. Cingulum NeuroSciences Institute has two business units. The main corporate CNSI is involved in basic research into the structure, connections, transmitter receptor and other protein localization, functions, and pathologies of cingulate cortex and its associated regions in the cerebral cortex, thalamus, and midbrain. Cingulate NeuroTherapeutics (CNT) is the clinical research and development arm of the company that provides imaging for CNS drug development and is involved in clinical research projects that seek to demonstrate the functional efficacy of pharmacological and cognitive therapeutics in a broad range of neuropsychiatric conditions. Both business units contribute to a Clinical Research Training program for Medical Residents.

Mission. We are neuroscientific entrepreneurs. We seek to maintain a high standard of scientific protocol, large morphological and imaging data bases, and cutting edge facilities to enhance our ability to add value as consultants and collaborators in the neuroscientific enterprise. An important aspect of our work and consultancies is to integrate multidisciplinary approaches to brain functions such as emotion, pain, learning and memory, and visuospatial processes for normal and diseased brain. We evaluate fundamental pathophysiological and biochemical processes through their differential impact on human brain, including cingulate cortex. We provide investigators with facts and strategies to productively study limbic cortex and we maintain an international resource on the neurobiology of limbic cortex. The practical outcome of our neuroscientific activities is available through activities of CNT, including diagnostic imaging.

Dr. Vogt's Brain

The company logo is a coregistration of structural magnetic resonance images (gray) of Dr. Vogt's brain and positron emission tomography images of binding of the opiate receptor antagonist diprenorphine that was labeled with radioactive carbon (11C). Heaviest binding is in red and is located mainly in anterior and middle parts of the cingulate gyrus. For further details of the localization of opiate binding on the medial surface of the human brain see Vogt, Watanabe, Grootoonk, and Jones (1995; Human Brain Mapping 3:1-12). The logo also has an immunohistochemical image of the SMI32 antibody in the caudal cingulate motor area in midcingulate cortex to show the aggregations of large layer Vb pyramidal neurons expressing high levels of intermediate neurofilaments that project to the spinal cord as discussed in detail by Vogt, Hof and Vogt (2004, Cingulate Gyrus, In: The Human Nervous System, G. Paxinos and J. Mai, eds; Elsevier, San Diego). The third image is a three-dimensional, eigenvector projection of values of neuron densities in posterior cingulate area 23 for five statistical subgroups of Alzheimer's disease (Vogt et al., 1998, Experimental Neurology 153:8-22). Multivariate statistics are an important part of the quantitative neuroanatomical strategies used by CNSI.

copyright 2004-2009 Cingulum NeuroSciences Institute. All rights reserved.
Brent A. and Leslie J. Vogt.