Cingulum NeuroSciences Institute, functions and pathologies of Cingulate Cortex



Book: Cingulate Neurobiology
and Disease


Neuroscientific Expertise


Cingulate NeuroTherapeutics

Localizing Cingulate

Cingulate Cortex

Rat Cingulate Cortex (PDF)

Monkey Cingulate Cortex (PDF)


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Rat Cingulate Cortex & Disease Models

Pain Processing, Cingulate Cortex and the Medical Pain System

A Psychiatrist’ Perspective on Cingulate Cortex

Alzheimer’s Disease

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Localizing Cingulate Subregions-of-Interest

Four strategies are evolving to localize the 8 cingulate subregions. In view of the extreme sulcal variability on the medial surface, none of these approaches depend significantly on sulcal limits to assess the subregions. Sulci are only used around the corpus callosum and to limit the dorsal edge of cingulate cortex in the first three. The ultimate goal is a map of each area determined from histological sections that does not involve sulci at all as will be available soon. The four strategies follow:

  1. A quick-and-dirty localization for Talairach space with control GPC case and a flat map shown here.
  2. A standardized approach for Talairach and ICBM152 that used GPC and the flat map (O'Niell et al., 2009; Chapter 36).
  3. Analyze software is being developed by Biomedical Imaging Resource.
  4. Dr. Nicola Palomero-Gallagher is voluming histologically defined cingulate areas in a probabilistic map of cingulate cortex.

Localizing Subregions

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2 TTCoRegGPC   view larger

3 TTCoordGPC

3 TTCoordGPC   view larger



4 FMGPC   view larger

5 SubFlatOrient

5 SubFlatOrient   view larger


6 FlatMap3Species

6 FlatMap3Species   view larger


Cingulate Neurobiology and Disease Chapter 36: Localizing Cingulate Subregions-of-Interest in Magnetic Resonance Images Guided by Cytological Parcellations by Joseph O’Neill, Thomas L. Sobel, and Brent A. Vogt.
View Chapter 36 Contents (PDF)

copyright 2004-2009 Cingulum NeuroSciences Institute. All rights reserved.
Brent A. and Leslie J. Vogt.